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Meld score normal range1/21/2024 ![]() This also fits the observed increased mortality in individuals with ALT values that are normal but above the healthy range. In that regard it has been suggested to use an upper limit of 19 and 30 U/L for ALT for women and men, respectively, 1 to reflect healthy values. Contrarily, being within the normal value does not necessarily reflect a healthy state. But being outside the normal does not immediately reflect illness that is, a bilirubin level below normal has no clinical consequences. ![]() Thus, 2.5% of a population will be above and below the normal values, respectively. Normal values for laboratory results are defined as those found in 95% of a population. Prolonged in liver disease, vitamin K deficiency, fat malabsorption, pancreatic insufficiencyĭiscrimination of Normal Versus Healthy Values Low in nephrotic syndrome, malnutrition, protein‐losing enteropathy Hemolysis, Gilbert syndrome, Crigler‐Najjar syndrome Severe liver injury from any cause Rotor syndrome, Dubin‐Johnson syndrome Hemolysis, insufficient excretion from the liver Liver, bone, placenta, kidneys, intestinesĬholestatic liver disease sarcoidosis pregnancy lymphoma bone, kidney, and intestinal diseasesīiliary epithelial cells, kidneys, pancreas, prostateīiliary or pancreatic disease, myocardial infarct, renal diseases, chronic lung disease, diabetes Hepatocellular injury of any cause, myopathies Hepatocellular injury of any cause, myopathies, myocardial infarct, hemolysis Liver, skeletal muscle, cardiac muscle, red blood cells, brain, pancreas, lungs The excretory function of the liver can be estimated by bilirubin and the metabolic function of the liver by clotting tests and albumin. Standard liver tests (Tables (Tables1 1 and and2) 2) that assess injury to the liver include alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatases (APs). Both the detection of enzymes released from liver cells and proteins produced by the liver and released into the blood can be used to analyze liver health. The liver is the largest organ in the body and arguably the most important organ for protein production and detoxification, both of which are facilitated by a myriad of enzymes. Abbreviations AIH autoimmune hepatitis ALT alanine aminotransferase AMA antimitochondrial antibodies AP alkaline phosphatase AST aspartate aminotransferase DILI drug‐induced liver injury ERCP endoscopic retrograde cholangiopancreatography gGT γ‐glutamyl transpeptidase LIT, liver injury test MELD Model for End‐Stage Liver Disease MRCP magnetic resonance cholangiopancreatography NASH nonalcoholic steatohepatitis PBC primary biliary cholangitis ULN upper limit of normal
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